Rams let a winnable Thursday slip away in OT against a short-handed 49ers, leaving Sean McVay furious and fantasy managers weighing risk and reward. Los Angeles sits at 3-2 after two gut-punch losses, with critical mistakes in special teams and ball security dragging down the win column. Puka Nacua remains the engine of the attack, piling up targets and yards behind a prolific Stafford, who’s averaging 300+ passing yards per game. Next up: a tough Baltimore test, then a London clash with Jacksonville.

Kendrick Bourne steps into fantasy relevance as the 49ers lean on a makeshift WR corps due to injuries, led by Bourne with backup help from Demarcus Robinson, Skyy Moore, and Marquez Valdes-Scantling. Bourne’s Patriots familiarity adds a spark, but the group remains volatile with Aiyuk on PUP and Kittle sidelined. In L.A., Kyren Williams rebounds with two receiving TDs, while Corum’s role shrinks after a late turnover. Ferguson flashes but the TE rotation keeps upside limited.

The Rams’ pass-catching mix shows upside for deeper leagues if injuries persist, with Atwell and Nacua providing shot-clock value. Adams’ and Nacua’s roles loom large for fantasy, while the 49ers must salvage the offense around Bourne and remaining veterans. Week 6 shapes up as a matchup-driven, risk-heavy slate for WR-heavy lineups.